Speaking on Thursday, WHO regional director Hans Kluge said 300,000 new infections were reported last week alone.
"We have a very serious situation unfolding before us," he said.
Some European countries, including the UK and France, have recorded their highest daily tallies in months.
Testing capacity has increased across Europe since the pandemic began, meaning that cases are now more likely to be identified and recorded.
But Mr Kluge said the new figures also showed "alarming rates of transmission across the region".
Hospital admissions and deaths have not yet seen a similar rise, although Spain and France are seeing an upward trend.
While younger people - who are less likely to be severely impacted if they are infected - currently make up the largest proportion of newly recorded coronavirus cases, there are fears of many more cases of serious illness if the virus spreads to older and more vulnerable groups.
According to the WHO, there have been five million confirmed cases and more than 228,000 fatalities across Europe since the pandemic began.
'Wake up call'
Mr Kluge told Thursday's briefing that lockdown measures introduced in the spring and early summer had produced clear results.
"In June cases hit an all-time low," he said. "The September case numbers, however, should serve as a wake-up call for all of us."
But he stressed that knowledge about the best ways to contain the virus had improved since the pandemic first spread to Europe.
"We have fought it back before and we can fight it back again," he said.
Earlier this week Mr Kluge warned that Europe should prepare for a rise in the number of coronavirus deaths in October and November, warning: "It's going to get tougher."
What's the situation around Europe?
France, meanwhile, recorded 10,593 cases on Thursday - the highest daily number since the pandemic began.
Health Minister Olivier Véran acknowledged the coronavirus "is again very active"; Lyon and Nice, two of France's biggest cities, have been given until Saturday to come up with new measures to tackle their outbreaks.
Mr Véran and Prime Minister Jean Castex are among several ministers facing legal action over their handling of the crisis.
Other countries are seeing their own spikes:
- Spain on Wednesday recorded 239 new coronavirus deaths, the highest number since June. Many of the country's new infections have been in the capital Madrid, where authorities are planning to announce new lockdown measures
- The Czech Republic has reported more than 2,000 daily cases for the first time. The country's prime minister called on people to follow the rules to prevent an exponential increase in infections
- Cases have also reached a new daily peak in the Netherlands, with the government expected to announce new coronavirus measures on Friday
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September 18, 2020 at 01:34AM
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Coronavirus: WHO says weekly cases in Europe eclipse March peak - BBC News
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